The COVID-2019 pandemic is a disease of serious concern for mankind and has been propagated globally, was initially seen at Wuhan, in China at the end of December 2019, and the further transmitted to almost 300 nations all over the world. This kind of lethal infection emerged from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). World Health Organization has affirmed COVID-19 as a pandemic on 11 March 2020. This review article briefly focused on the etiology, pathophysiology, histopathology, different types of variants (VoC & VoI), and diagnostic ways for combating COVID-19. Authors addressed the natural and synthetic therapy for the control of COVID-19 and concluded that natural therapies having less toxicity to human beings rather than synthetic therapies. The recent discoveries and advancements have been expeditiously done for combating COVID-19 with the help of antibody preparations and development of novel vaccines. This article also highlights the importance of NDDS for the prevention of COVID-19 and emphasized the study of recently found various variants of SARS-CoV-2 and their prevention for further spreading.