Background: Drug misuse is the most frequently discussed psychological issue among adolescents and teenagers in both developed and developing countries. Drug addiction is a global problem among the youth and older people, though the rate of usage by the youth is higher than that of the older people. Objectives: The study aim to evaluation of students’ knowledge about drugs abuse, and identify Difference between students’ knowledge and sociodemographic characteristics. Methods: Descriptive study design among 200 students selected by non-probability sampling (convenience sample). The study tool is a questionnaire composed from two parts (socio demographic characteristics and knowledge scale). The data collected by interview method at Al-Maarif College in Al-Ramady Ciy. Result: The finding indicated that 68(34%) of students at age (19-21) years contributed among first and second stage from Al-Maarif college, 106(53%) are males, 124(62%) of them have moderate socioeconomic status. 74% of students had moderate level of knowledge about drugs abuse at mean and standard deviation was (67.45±13.84). There is significant statistical relationship between students’ knowledge with age, sex and socioeconomic status at p value (0.000, 0.000, and 0.003) respectively. Conclusion: Sudents had moderate level of knowledge about drugs misuse. Medical education has continuously been respected as profoundly demanding.