Introduction: Prostate cancer (PCa) is the second most frequent cancer diagnosed in men and fifth leading cause of death worldwide. Aim: investigates the prognostic role of mpMRI by evaluating the correlation of PIRADS with histopathology. Methods: This study was conducted at department of Radiodiagnosis at S.P. Medical College Bikaner. 50 patients were included in study fulfilling inclusion and exclusion criteria. The image interpretation and categorization of prostate nodules was done using PIRADS criteria and findings obtained was compared with histopathological report obtained by TRUS guided BIOPSY. Results: The mean age of the patients was 65 year with age range of 45-89 years. The overall cancer detection rate was 58 % (29/50) patients. On analysis of PIRADS ≥3 nodules on MRI the sensitivity, specificity, positive predictive value (PPV) ,negative predictive value (NPV) were 60.8%, 75%,96% and 14.2% respectively. Conclusion: PIRADS ≥ 3 had high specificity and high positive predictive value for Prostate cancer using biopsy results as the standard of reference.