Contents
Download PDF
pdf Download XML
617 Views
31 Downloads
Share this article
Research Article | Volume: 22 Issue 2 (December, 2023) | Pages 257 - 264
Non neoplastic laryngeal causes of voice disorders – A Comprehensive Study
 ,
 ,
1
Professor and HOD, Department of ENT, Vinayaka Missions Kirupananda Variyar Medical College, Vinayaka Mission's Research Foundation (DU), Salem, Tamil Nadu, India.
2
Junior Resident, Department of ENT, Vinayaka Missions Kirupananda Variyar Medical College, Salem. Vinayaka Mission's Research Foundation (DU), Salem, Tamil Nadu, India.
3
junior Resident, Department of ENT, Vinayaka Missions Kirupananda Variyar Medical College, Salem. Vinayaka Mission's Research Foundation (DU), Salem, Tamil Nadu, India.
Under a Creative Commons license
Open Access
Received
July 27, 2023
Revised
Aug. 23, 2024
Accepted
Aug. 27, 2024
Published
Aug. 29, 2024
Abstract

Introduction: Non neoplastic lesions of vocal cord are a spectrum of laryngeal diseases, in which the patients suffer from various symptoms like hoarseness of voice, throat discomfort, pain in the throat. With timely diagnosis and intervention, the prognosis will be good. Methodology: A prospective study with 60 patients clinically diagnosed with nonmalignant lesions of larynx who attended ENT OPD, VMKVMCH, Salem. After history taking, ENT examination, patients with suspected benign lesions of larynx were examined with video laryngoscopy and diagnosis was made and patients were managed accordingly and followed up for a period of 3 months. Results: In our study, mean age was 45.21±6.61 years. 60% of the patients were male, 40% were female.71.7% of the cases presented with hoarseness of voice, 70% of cases had vocal fatigue, 96.7% had foreign body sensation, 48.3% had dysphagia, 28.3% had neck swelling, 45% had history of weight loss.  35% had smoking habit, 35% had habit of alcohol, 45% had habit of chewing pan and betel nut, 58.3% had history of vocal abuse and 55% were having poor oral hygiene. In our study, it was observed that 5% of the cases had chronic laryngitis ,1.7% had contact ulcers, 21.7% had cysts, 5% had granulomas, 1.7% had papilloma, 5% had Reinke’s edema, 1.7% had Tuberculous laryngitis, 15% had vocal nodules, 43.3% had vocal polyp.

 53% of the patients were managed by micro laryngeal surgery and speech therapy, 46% were managed by medical and speech therapy.  The success rate was 89% following micro laryngeal surgery and speech therapy, 85% following medical and speech therapy. Conclusion: Early diagnosis of the non-neoplastic lesions can lead to effective management.   Micro laryngeal surgery and voice rest offer a cost effective, useful and safe method for management of benign laryngeal lesion.

Keywords
INTRODUCTION

Voice is the sound made by the vibration of vocal folds caused by air passing out through the larynx and the upper respiratory tract, the focal fold being approximated. The vocal cords extend through the laryngeal cavity bilaterally and are primarily responsible for voice production. Phonation is the process by which vocal folds produce certain sounds through quasi periodic vibration. Voice disorders occur with changes in pitch, volume, tone and other quality of voice.

 

The various causes of voice disorders can be due to structural, inflammatory, traumatic causes and laryngopharyngeal reflux. This study was done to analyses the various causes of voice disorders and their management strategies due to nonmalignant lesions of larynx in patients who attended ENT department, in the period of our study.

MATERIAL AND METHODS

A prospective study with 60 patients from June 2022 to May 2023 clinically diagnosed with voice disorders in nonmalignant lesions of larynx who attended our OPD.  After detailed history taking and thorough clinical examination, these patients were subjected to routine blood investigations, patient with suspected benign lesions of larynx were examined with video laryngoscopy and the underlying causes of voice disorder was diagnosed and they were managed appropriately and followed up for 3 months

RESULTS

In our study, 11.7% of participants were aged 31-35 years, 20% were aged 36-40 years , 15% were aged 41 -45 years, 28.3% were aged 46-50 years, 25% were aged 51-55 years . 

 

 

60% of patients were male and 40% were female

 

8.3% of the patients belonged to upper middle class ,38.3% belonged to lower middle class,  41.7% belonged to upper lower class, 11.7% belonged to lower class

 

In our study 36.7% were agricultural labourers, 21.7% were into business , 25% were housewives, 16.6%  were teachers.

 

Clinical presentation:

Clinical presentation

         Frequency

        Percentage

Hoarseness

43

71.7

Vocal fatigue

42

70

Foreign body sensation

58

96.7

Dysphagia

29

48.3

Cough

28

46.7

Neck swelling

17

28.3

Dyspnea

1

1.6

Neck pain

17

28.3

Weight loss

27

45

Blood stained sputum

2

3.3

 

 

35% of the cases had habit of smoking, 35% of the caes had habit of alcohol intake, 45% has betel nut chewing habit , 35% had tobacco chewing habit, 58.3% had habit of vocal abuse and 55% were having poor dental hygiene.

 

5% of the patients had chronic laryngitis, 1.7% had contact ulcers, 21.7% had cysts ,5% had granulomas, 1.7% had papilloma, 5% had Reinke’s edema, 1.7% had Tuberculous laryngitis, 15% had vocal nodules, 43.3% had vocal polyp.

 

Vocal cord lessions were more commomly seen among cases of advanced age group. There was a statistically significant association between gender and vocal cord lessions. Male gender was frequently associated with vocal cord lessions. It was observed that more number of house wives had vocal cord lessions.

Treatment:

  Management

     Frequency

      Percentage

Microlaryngeal surgery and speech therapy

         32

           53%

Medical and speech therapy

         28

           46%

 

 

Management

  Success rate

Microlaryngeal surgery and speech therapy

                 89%

Medical and speech therapy

                 85%

 

 

Follow up:

Voice recovery

    Frequency

  Percentage

Improved

            54

          90%

Not improved

            6

          10%

Total

            60                                  

           100%

 

DISSCUSION

Benign lessions of larynx constitute an interesting array of lessions. These lessions were defined as abnormal mass of tissue in the larynx, the growth of which exceeds and is uncoordinated with that of normal tissue and persist in the same excessive manner after cessation of stimuli which evoke the change. Benign lessions such as vocal nodules, vocal polyps, intracordal cyst, mucosal haemorrhage seems to be due to vibratory trauma. Secondary influences like smoking, allergy, acid reflux, infection may increase the mucosa’s vulnerability to the kind of injuries that may occur during mucosal oscillation.

 

In the study done by Singhal P et al., the most common complaints were hoarseness of voice, cough, foreign body sensation and throat pain, in our study the most common complaints were hoarseness, voice fatigue, foreign body sensation and dysphagia.

 

In the study done by Chaitanya V et al., majority of the patients suffered the symptoms from a duration of 15 days to 1.5 years. In our study, 3.3% of the patients had symptoms for <1 week, 20% of the cases had symptoms for more than a week to 1 month ,60% of cases had symptoms for more than a month to 6 months, 16.7% cases had for more than 6 months.

 

In our study, it was observed that there was a significant association between personal habits and vocal cord lessions. It was observed that chewing of pan, vocal abuse and poor orodental hygiene were frequently associated with vocal cord lessions. In the study conducted by Chaitanya V et al., they have observed that among neoplastic lessions 50% of the cases had history of tobacco smoking in the form of cigarette, 33.3% had alcohol addiction, 6.8% had both smoking and alcohol history ,3.3% had betelnut chewing history, 3.3% had history of toacco chewing.

 

In our study, it was observed that 5% of the cases had chronic laryngitis ,1.7% had contact ulcers, 21.7% had cysts, 5% had granulomas, 1.7% had papilloma, 5% had Reinke’s edema, 1.7% had Tuberculous laryngitis, 15% had vocal nodules, 43.3% had vocal polyp. In the study done by Chaitanya V et al., the non-neoplastic lessions constituted about 62.5% of cases with vocal polyp being the commonest type seen in 33.7%, the second most common cause noted was vocal cord nodule 22.22%.

 

In our study 53% of the patients were managed by microlaryngeal surgery and speech therapy, 46% were managed by medical and speech therapy whereas in the study done by Singhal P et al; 96% of the patients were managed by surgery and voice rest, 6% were managed by speech therapy.

 

In our study, the success rate was 89% following microlaryngeal surgery and speech therapy, 85% following medical and speech therapy. In the study done by Singhal P et al; 93.6% of the patients were normal without any recurrence after microlaryngeal surgery followed by speech therapy.

CONCLUSION

The laryngeal dysfunction produces symptoms which can vary from mild hoarseness to life threatening stridor. Laryngeal lessions can create lot of mental and emotional tension in the patient and family. Early diagnosis of the lesion can lead to effective management. All available methods of study should be utilized to make the diagnosis as early as possible. Microlaryngeal surgery and voice rest offer a cost effective, useful and safe method for management of benign laryngeal lesion.

REFERENCE
  1. Singhal P, Bhandari A, Chouhan M, Sharma MP, Sharma S et al. Benign tumors of larynx: A clinical study of 50 cases .Ind J Otolaryngol Head Neck Surg 2009, [suppl 1] ;26-30
  2. Chaitanya V, Nikethan B. Clinicopathological study of non neoplastic and neoplastic lessions of larynx. Int J Intg Med Sci 2015;2[12]:200-5
  3. Goswami S, Patra TK. A Clinicopathological study of Reinke’s oedema. Indian Journal of otolaryngology and Head and Neck surgery. 2003 Jul;55(3):160-5
  4. Wedrychowicz B, Nijander D, Betkowski A, Jastrzebski J. Reinke’s edema and thyroid hypofunction . Otolaryngology. 1992;46(6):538-542.
  5. Hojslet EE, Moesgaard- Nielsen V, Karlsmose M. Smoking cessation in chronic Reinke’s oedema. The Journal of Laryngology and Otology. 1990;104:626-628.
  6. Parikh N. Aetielogy study of 100 cases of hoarseness of voice. Indian J Otolaryngology Head neck surgery 1991;43(2):71-3.
  7. Doloi PK, Khanna S. A study of Management of Benign Lesions of the Larynx. International Journal of Phonosurgery and Laryngology. 2011 Dec;1(2):61-4.
  8. Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, Strojan P , Bradley PJ, Rinaldo A. Squamous epithelial changes of the larynx: diagnosis and therapy . Head and neck. 2012 Dec; 34(12):1810-6.
  9. Koufman JA. Gastroesophageal reflux and voice disorders. Diagnosis and treatment of voice disorders. New York: Igaku-Shoin. 1995:161-75.
  10. Bhagat R. Histopathological Study of Non Neoplastic and Neoplastic Lesions of Larynx. Jmscr [Internet]. 2019 Apr 19 [Cited 2022 Jul 21];7(4). Available from : http://jmscr.igmpublication.org/v7-i4/110%20jmscr.pdf.
  11. Bharathi Mohan Mathan. A study on non-malignant lesion of larynx. International Journal of Otorhinolaryngology and Head and Neck Surgery. 2018 Apr 26;4(3):655-8.
  12. Marcotullio D, Magliulo G, Pezone T. Reinke’s edema and risk factors: clinical and histopathologic aspects. American journal of otolaryngology. 2002 Mar 1(2):81-4.
  13. Ghandour HH , Hadhoud YH, ElFiky YH. Screening for dysphagia in dysphonic patients with non- neoplastic vocal fold lesions by Arabic EAT-10: cross sectional study. The Egyptian Journal of Otolaryngology. 2021 Dec;37(1):1-5.
  14. Ghosh SK, Chattopadhyay S, Bora H, Mukherjee PB. Microlaryngoscopic study of 100 cases of hoarseness of voice. Indian J Otolaryngol Head Neck Surg 2001;53(4);270-2.
  15. Bakshi J, Panda NK, Sharma S, Gupta AK, Mann SBS. Survival patterns in treated cases of carcinoma larynx in North India: a 10 years follow up study.  Ind J Otolaryngol Head Neck Surg. 2004;56(2):99-103.
  16. Rosai J. Larynx and Trachea . Surgical Pathology . 10th Philadelphia:Elsevier;2011.pp. 320-323.
  17. Pohunek P. Development, structure and function of the upper airways. Pediatric respiratory reviews. 2004 Mar 1;5(1):2-8.
  18. Chandramouli MP, Sengottuvelu P, Vivek B. Non-malignant lesions of larynx-Our experience. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS).2018;17(2):54-7.
  19. Duflo SM, Thibeault SL, Li W, Smith ME, Schade G, Hess MM. Differential gene expression profiling of vocal fold polyps and Reinke’s edema by complementary DNA microarray. The Annals of Otology, Rhinology, and Laryngology. 2006;115:703-714.
  20. Sakae FA, Imamura MD, Sennes L, Mauad T, Saldiva P, Tsuji DH. Disarrangement of collagen fibres in Reinke’s edema. The Laryngoscope . 2008;118:1500-1503.
Recommended Articles
Research Article
Actual issues of higher pharmaceutical education
Download PDF
Research Article
Immunogenic properties of viper (Vipera Lebetina) venom
...
Download PDF
Research Article
Technological methods of preparation of “Insanovin” tablet
Download PDF
Research Article
Study of lipids of some plants from the flora of Azerbaijan
Download PDF
Chat on WhatsApp
© Copyright None